%PDF-1.7
%
90 0 obj
<>
endobj
79 0 obj
<>
endobj
89 0 obj
<>stream
Acrobat Distiller 8.1.0 (Windows)
2020-08-25T21:37:46+08:00
Arbortext Advanced Print Publisher 9.1.440/W Unicode
2020-10-13T17:41:04-07:00
2020-10-13T17:41:04-07:00
uuid:d8d03d34-7dd1-4a77-a758-95aeea9fbb64
uuid:5ad7185b-1dd2-11b2-0a00-1e00589b91ff
application/pdf
Science Journals — AAAS
endstream
endobj
76 0 obj
<>
endobj
2 0 obj
<>
endobj
78 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Thumb 73 0 R/Type/Page>>
endobj
1 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Thumb 3 0 R/Type/Page>>
endobj
26 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Thumb 27 0 R/Type/Page>>
endobj
35 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Thumb 36 0 R/Type/Page>>
endobj
45 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Thumb 46 0 R/Type/Page>>
endobj
57 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Thumb 58 0 R/Type/Page>>
endobj
152 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
172 0 obj
[178 0 R 179 0 R 180 0 R 181 0 R 182 0 R 183 0 R]
endobj
173 0 obj
<>stream
q
87.5 0 0 21.75 72 662.25 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
10 0 0 10 72 611.99997 Tm
(ketones)Tj
35.78084 1 Td
(-substituted)Tj
/T1_1 1 Tf
-0.54899 0 Td
(b)Tj
/T1_0 1 Tf
-35.23185 0 Td
(Static to inducibly dynamic stereocontrol: The convergent use of racemic\
)Tj
ET
BT
/T1_2 1 Tf
8 0 0 8 72 590.99997 Tm
(MacMillan and Todd K. Hyster)Tj
0 1 TD
(Jacob S. DeHovitz, Yong Yao Loh, Jacob A. Kautzky, Kazunori Nagao, Andre\
w J. Meichan, Motoshi Yamauchi, David W. C.)Tj
ET
BT
/T1_2 1 Tf
8 0 0 8 72 544.99997 Tm
(DOI: 10.1126/science.abc9909)Tj
5.50301 1 Td
( \(6507\), 1113-1118.)Tj
/T1_0 1 Tf
-1.668 0 Td
(369)Tj
/T1_3 1 Tf
-3.83501 0 Td
(Science\240)Tj
ET
BT
/T1_2 1 Tf
8 0 0 8 145.45605 464.99982 Tm
(, this issue p. 1113)Tj
/T1_3 1 Tf
-3.55701 0 Td
(Science)Tj
/T1_2 1 Tf
-3.125 1 Td
(position has typically been considered too configurationally stable for \
a DKR approach.)Tj
/T1_1 1 Tf
49.84696 1.00001 Td
(b)Tj
/T1_2 1 Tf
-20.17498 0 Td
(-substituted ketones into chiral alcohols. This )Tj
/T1_1 1 Tf
-0.54899 0 Td
(b)Tj
/T1_2 1 Tf
-29.12299 0 Td
(photoredox catalysis, and enzymatic catalysis to achieve DKR of )Tj
29.12397 1 Td
( report cooperative application of organocatalysis,)Tj
/T1_3 1 Tf
-2.168 0 Td
(et al.)Tj
/T1_2 1 Tf
-26.95597 0 Td
(them is being more efficiently funneled to product. DeHovitz )Tj
52.57689 1.00001 Td
(of)Tj
-52.57689 0 Td
(of the two possible mirror-image products. The key is to find a means of\
rapidly interconverting the reactants while one )Tj
3.125 1 Td
(Dynamic kinetic resolution \(DKR\) is a powerful method to transform a p\
air of mirror-image reactants into just one)Tj
/T1_0 1 Tf
-3.125 1 Td
(Expanding the kinetic resolution purview)Tj
ET
BT
/T1_0 1 Tf
6 0 0 6 79 399 Tm
(ARTICLE TOOLS)Tj
ET
BT
0 0 1 rg
/T1_2 1 Tf
8 0 0 8 187 397 Tm
(http://science.sciencemag.org/content/369/6507/1113)Tj
ET
BT
0 g
/T1_0 1 Tf
6 0 0 6 79 356.99997 Tm
(MATERIALS)Tj
0 1.00001 TD
(SUPPLEMENTARY )Tj
ET
BT
0 0 1 rg
/T1_2 1 Tf
8 0 0 8 187 361 Tm
(http://science.sciencemag.org/content/suppl/2020/08/27/369.6507.1113.DC1\
)Tj
ET
BT
0 g
/T1_0 1 Tf
6 0 0 6 79 321 Tm
(REFERENCES)Tj
ET
BT
0 0 1 rg
/T1_2 1 Tf
8 0 0 8 187 310.99997 Tm
(http://science.sciencemag.org/content/369/6507/1113#BIBL)Tj
0 g
0 1 TD
(This article cites 55 articles, 5 of which you can access for free)Tj
ET
BT
/T1_0 1 Tf
6 0 0 6 79 285 Tm
(PERMISSIONS)Tj
ET
BT
0 0 1 rg
/T1_2 1 Tf
8 0 0 8 187 283 Tm
(http://www.sciencemag.org/help/reprints-and-permissions)Tj
ET
BT
/T1_2 1 Tf
8 0 0 8 193.38391 128 Tm
(Terms of Service)Tj
0 g
-15.17299 0 Td
(Use of this article is subject to the )Tj
ET
72 114 m
521 114 l
0 0 m
S
BT
ET
BT
/T1_2 1 Tf
8 0 0 8 357.45605 93.99997 Tm
( is a registered trademark of AAAS.)Tj
/T1_3 1 Tf
-3.55701 0 Td
(Science)Tj
/T1_2 1 Tf
-32.125 0 Td
(Science, 1200 New York Avenue NW, Washington, DC 20005. The title )Tj
3.83501 1 Td
(\(print ISSN 0036-8075; online ISSN 1095-9203\) is published by the Amer\
ican Association for the Advancement of)Tj
/T1_3 1 Tf
-3.83501 0 Td
(Science )Tj
ET
BT
/T1_2 1 Tf
8 0 0 8 72 71.99997 Tm
(Science. No claim to original U.S. Government Works)Tj
T*
(Copyright \251 2020 The Authors, some rights reserved; exclusive license\
e American Association for the Advancement of)Tj
ET
BT
/T1_2 1 Tf
0 -8 8 0 575 326.8761 Tm
(on October 13, 2020)Tj
-0.278 0 Td
( )Tj
0 0 1 rg
-13.50598 0 Td
(http://science.sciencemag.org/)Tj
0 g
-8.11398 0 Td
(Downloaded from )Tj
ET
endstream
endobj
177 0 obj
<>/Filter/FlateDecode/Height 87/Length 19684/Name/X/Subtype/Image/Type/XObject/Width 350>>stream
HyTS߽Ia
"6p\P縠x:Z.Suk:8ud,EԺУ:xtSVk9@na}/ Ҟ6Gy@{_rcL"bFSgjz"UH}>2Z
5f @a,uWP24
jѨ\i-~==Op(rw]EQڇMyƧH4E5(HQ_-*P1.#*kb"f_+XA¾ՆK$FxUFJeFq {vdcg8ZS#3_kX `9'p (3u_Od}uvn|TSI#
!y 3|].Fh{U_JA-M0bD22}[-(U~[yTk|H mL;ƶc 0X ?1Ar?oƀU]C:/^ّ,7(a"Gq?b#QUaS L6)$Hm[ANc tPĎvURl2!VV{^e(^I9Dã3l]]\3$!i;v{?.Ҕ}31,ER[^k4Nok#b7fIȐy`au^GUĉ
W&\y,$d<|rD;VӪn>Mј[Mi#DQ LY2Cme#BV~2`ls~s W&
=xAJE^dɡ>S=`_dgk+gqaنKgbK=E[> @AQbg(