Publications

Aminoalkylation of Alkenes Enabled by Triple Radical Sorting.

Parallel Proteomic and Transcriptomic Microenvironment Mapping (µMap) of Nuclear Condensates in Living Cells

Iron-Catalyzed Cross-Electrophile Coupling for the Formation of All-Carbon Quaternary Centers

μMap-Interface: Temporal Photoproximity Labeling Identifies F11R as a Functional Member of the Transient Phagocytic Surfaceome

µMap proximity labeling in living cells reveals stress granule disassembly mechanism.

Unlocking Carbene Reactivity by Metallaphotoredox α-Elimination.

Engaging Alkenes in Metallaphotoredox: A Triple Catalytic, Radical Sorting Approach to Olefin-Alcohol Cross Coupling

Current advances in photocatalytic proximity labeling

Triple Radical Sorting: Aryl-Alyklation of Alkenes

Free-Radical Deoxygenative Amination of Alcohols via Copper Metallaphotoredox Catalysis

Development of a General Organophosphorus Radical Trap: Deoxyphosphonylation of Alcohols

Direct Bioisostere Replacement Enabled by Metallaphotoredox Deoxydifluoromethylation

Couple-close Construction of Polycyclic Rings from Diradicals

Alcohol-alcohol cross-coupling enabled by SH2 radical sorting

Redefining the Synthetic Logic of Medicinal Chemistry. Photoredox- Catalyzed Reactions as a General Tool for Aliphatic Core Functionalization

Exploiting the Marcus inverted region for first-row transition metal–based photoredox catalysis

Photoredox Catalysis-Enabled Sulfination of Alcohols and Bromides

Rapid and Modular Access to Quaternary Carbons from Tertiary Alcohols via Bimolecular Homolytic Substitution

μMap Photoproximity Labeling Enables Small Molecule Binding Site Mapping

General Access to Cubanes as Benzene Bioisosteres

Tracking chromatin state changes using nanoscale photo-proximity labelling

Expedient Access to Underexplored Chemical Space: Deoxygenative C(sp3)–C(sp3) Cross-Coupling

Late-Stage C(sp3)−H Methylation of Drug Molecules

Rapid Access to 2‐Substituted Bicyclo[1.1.1]pentanes

Photoproximity Labeling of Sialylated Glycoproteins (GlycoMap) Reveals Sialylation-Dependent Regulation of Ion Transport

Carboxylic Acids as Adaptive Functional Groups in Metallaphotoredox Catalysis

Nickel Catalysis via SH2 Homolytic Substitution: The Double Decarboxylative Cross-Coupling of Aliphatic Acids

Photochemical Identification of Auxiliary Severe Acute Respiratory Syndrome Coronavirus 2 Host Entry Factors Using μMap

Radius measurement via super-resolution microscopy enables the development of a variable radii proximity labeling platform

Deoxytrifluoromethylation of Alcohols

Alcohols as Alkylating Agents: Photoredox-Catalyzed Conjugate Alkylation via In Situ Deoxygenation

Bioinspired Supercharging of Photoredox Catalysis for Applications in Energy and Chemical Manufacturing

Accelerating reaction generality and mechanistic insight through additive mapping

A Unified Approach to Decarboxylative Halogenation of (Hetero)aryl Carboxylic Acids

Decarboxylative Borylation and Cross-Coupling of (Hetero)aryl Acids Enabled by Copper Charge Transfer Catalysis

μMap-Red: Proximity Labeling by Red Light Photocatalysis

Nontraditional Fragment Couplings of Alcohols and Carboxylic Acids: C(sp3)–C(sp3) Cross-Coupling via Radical Sorting

Metallaphotoredox: The Merger of Photoredox and Transition Metal Catalysis

Selective Isomerization via Transient Thermodynamic Control: Dynamic Epimerization of trans to cis Diols

Small molecule photocatalysis enables drug target identification via energy transfer

A biohybrid strategy for enabling photoredox catalysis with low-energy light

A biomimetic SH2 cross-coupling mechanism for quaternary sp3-carbon formation

Metallaphotoredox-enabled deoxygenative arylation of alcohols

Synthesis of Enantiopure Unnatural Amino Acids by Metallaphotoredox Catalysis

Site-selective tyrosine bioconjugation via photoredox catalysis for native-to-bioorthogonal protein transformation

Decatungstate-Catalyzed C(sp3)−H Sulfinylation: Rapid Access to Diverse Organosulfur Functionality

A general N-alkylation platform via copper metallaphotoredox and silyl radical activation of alkyl halides

The Application of Pulse Radiolysis to the Study of Ni(I) Intermediates in Ni-Catalyzed Cross-Coupling Reactions

Rapid Optimization of Photoredox Reactions for Continuous-Flow Systems Using Microscale Batch Technology

Reactive intermediates for interactome mapping

Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery

Site-Selective Functionalization of Methionine Residues via Photoredox Catalysis

Metallaphotoredox Perfluoroalkylation of Organobromide

Decarboxylative Oxygenation via Photoredox Catalysis

Mechanistic Analysis of Metallaphotoredox C−N Coupling:Photocatalysis Initiates and Perpetuates Ni(I)/Ni(III) Coupling Activity

Static to inducibly dynamic stereocontrol: The convergent use of racemic β-substituted ketones

HARC as an open-shell strategy to bypass oxidative addition in Ullmann–Goldberg couplings

Cross-Electrophile Coupling of Unactivated Alkyl Chlorides

The merger of decatungstate and copper catalysis to enable aliphatic C(sp3)–H trifluoromethylation

Microenvironment mapping via Dexter energy transfer on immune cells

Copper-mediated synthesis of drug-like bicyclopentanes

Transient Absorption Spectroscopy Offers Mechanistic Insights for an Iridium/Nickel-Catalyzed C−O Coupling

Open-Shell Fluorination of Alkyl Bromides: Unexpected Selectivity in a Silyl Radical-Mediated Chain Process

A Metallaphotoredox Strategy for the Cross-Electrophile Coupling of Alpha-Chloro Carbonyls with Aryl Halides

Photoredox-catalyzed deoxyfluorination of activated alcohols with Selectfluor

**Tetrahedron Prize for Creativity in Organic Chemistry, Steve Buchwald

Copper-Catalyzed Trifluoromethylation of Alkyl Bromides

Metallaphotoredox-Catalyzed Cross-Electrophile Csp3−Csp3 Coupling of Aliphatic Bromides

Metallaphotoredox Difluoromethylation of Aryl Bromides

Direct arylation of strong aliphatic C–H bonds

Decarboxylative sp3 C–N coupling via dual copper and photoredox catalysis

Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids

Decarboxylative Hydroalkylation of Alkynes

Selective Hydrogen Atom Abstraction through Induced Bond Polarization: Direct α-Arylation of Alcohols through Photoredox, HAT, and Nickel Catalysis

Sulfonamidation of Aryl and Heteroaryl Halides through Photosensitized Nickel Catalysis

Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols

Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials

Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

Direct Aldehyde C–H Arylation and Alkylation via the Combination of Nickel, Hydrogen Atom Transfer, and Photoredox Catalysis

Catalyst-Controlled Oligomerization for the Collective Synthesis of Polypyrroloindoline Natural Products

The Merger of Transition Metal and Photocatalysis

Direct, Enantioselective α-Alkylation of Aldehydes using Simple Olefins

Selective sp3 C–H Alkylation via Polarity-Match-Based Cross-Coupling

A General Small-Scale Reactor to Enable Standardization and Acceleration of Photocatalytic Reactions

Photosensitized, Energy Transfer-Mediated Organometallic Catalysis Through Electronically Excited Nickel(II)

Alcohols as Latent Coupling Fragments for Metallaphotoredox Catalysis: sp3–sp2 Cross-Coupling of Oxalates with Aryl Halides

Metallaphotoredox-Catalysed sp3–sp3 Cross-Coupling of Carboxylic Acids with Alkyl Halides

Photoredox Catalysis in Organic Chemistry

Aryl Amination Using Ligand-Free Ni(II) Salts and Photoredox Catalysis

Silyl Radical Activation of Alkyl Halides in Metallaphotoredox Catalysis: A Unique Pathway for Cross-Electrophile Coupling

Native Functionality in Triple Catalytic Cross-Coupling: sp3 C–H Bonds as Latent Nucleophiles

Oxy-Allyl Cation Catalysis: An Enantioselective Electrophilic Activation Mode

Enantioselective Decarboxylative Arylation of α-Amino Acids via the Merger of Photoredox and Nickel Catalysis

Fragment Couplings via CO2 Extrusion−Recombination: Expansion of a Classic Bond-Forming Strategy via Metallaphotoredox

Oxalates as Activating Groups for Alcohols in Visible Light Photoredox Catalysis: Formation of Quaternary Centers by Redox-Neutral Fragment Coupling

O–H Hydrogen Bonding Promotes H-Atom Transfer from a C–H bonds for α-Alkylation of Alcohols

Alcohols as Alkylating Agents in Heteroarene C–H Functionalization

Switching on Elusive Organometallic Mechanisms with Photoredox Catalysis

Enantioselective α-Alkylation of Aldehydes by Photoredox Organocatalysis: Rapid Access to Pharmacophore Fragments from β-Cyanoaldehydes

Selective Radical−Radical Cross-Couplings: Design of a Formal β‑Mannich Reaction

Merging Photoredox and Nickel Catalysis: The Direct Synthesis of Ketones by the Decarboxylative Arylation of α-Oxo Acids

Decarboxylative Fluorination of Aliphatic Carboxylic Acids via Photoredox Catalysis

The Direct Arylation of Allylic sp3 C–H Bonds via Organic and Photoredox Catalysis

Merging Photoredox and Nickel Catalysis: Decarboxylative Cross-Coupling of Carboxylic Acids with Vinyl Halides

Direct α-Arylation of Ethers through the Combination of Photoredox–Mediated C–H Functionalization and the Minisci Reaction

Activation of C−H Bonds via the Merger of Photoredox and Organocatalysis: A Coupling of Benzylic Ethers with Schiff Bases

Amine α-Heteroarylation via Photoredox Catalysis: A Homolytic Aromatic Substitution Pathway

Photoredox α‑Vinylation of α‑Amino Acids and N‑Aryl Amines

Carboxylic Acids as A Traceless Activation Group for Conjugate Additions: A Three-Step Synthesis of (±)-Pregabalin

Merging Photoredox with Nickel Catalysis: Coupling of α-Carboxyl sp3-Carbons with Aryl Halides

Direct β‑Alkylation of Aldehydes via Photoredox Organocatalysis

A General and Enantioselective Approach to Pentoses: A Rapid Synthesis of PSI-6130, the Nucleoside Core of Sofosbuvir

Decarboxylative Arylation of α‑Amino Acids via Photoredox Catalysis: A One-Step Conversion of Biomass to Drug Pharmacophore

A General Strategy for Organocatalytic Activation of C−H Bonds via Photoredox Catalysis: Direct Arylation of Benzylic Ethers

Direct β‑Functionalization of Cyclic Ketones with Aryl Ketones via the Merger of Photoredox and Organocatalysis

Simple Catalytic Mechanism for the Direct Coupling of α‑Carbonyls with Functionalized Amines: A One-Step Synthesis of Plavix

Enantioselective Total Synthesis of (−)-Minovincine in Nine Chemical Steps: An Approach to Ketone Activation in Cascade Catalysis

Enantioselective α‑Alkenylation of Aldehydes with Boronic Acids via the Synergistic Combination of Copper(II) and Amine Catalysis

Enantioselective Direct α‑Amination of Aldehydes via a Photoredox Mechanism: A Strategy for Asymmetric Amine Fragment Coupling

Enantioselective Intramolecular Aldehyde α‑Alkylation with Simple Olefins: Direct Access to Homo-Ene Products

Development of a generic activation mode: nucleophilic α-substitution of ketones via oxy-allyl cations

Nine-Step Enantioselective Total Synthesis of (−)-Vincorine

Photoredox Activation for the Direct β-Arylation of Ketones and Aldehydes

Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis

Enantioselective Organo-SOMO Cycloadditions: A Catalytic Approach to Complex Pyrrolidines from Olefins and Aldehydes

Enantioselective Copper-Catalyzed Construction of Aryl Pyrroloindolines via an Arylation−Cyclization Cascade

Enantioselective α-Vinylation of Aldehydes via the Synergistic Combination of Copper and Amine Catalysis

Synergistic Catalysis: A Powerful Synthetic Strategy for New Reaction Development

A General Approach to the Enantioselective α-Oxidation of Aldehydes via Synergistic Catalysis

Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis

Discovery of an α-Amino C–H Arylation Reaction Using the Strategy of Accelerated Serendipity

Enantioselective α-Arylation of Carbonyls via Cu(I)-Bisoxazoline Catalysis

Collective Synthesis of Natural Products By Means of Organocascade Catalysis

Photoredox Catalysis: A Mild, Operationally Simple Approach to the Synthesis of α-Trifluoromethyl Carbonyl Compounds

The Intramolecular Asymmetric Allylation of Aldehydes via Organo-SOMO Catalysis: A Novel Approach to Ring Construction

Enantioselective α-Arylation of Aldehydes via the Productive Merger of Iodonium Salts and Organocatalysis

Enantioselective Organocatalytic α-Fluorination of Cyclic Ketones

Total Synthesis of Diazonamide A

The Preparation of (2R,5S)-2-t-butyl-3,5- Dimethylimidazolidin-4-one

Direct and Enantioselective α-Allylation of Ketones via Singly Occupied Molecular Orbital (SOMO) Catalysis

*** Special Issue on Organocatalysis

Enantioselective α-Benzylation of Aldehydes via Photoredox Organocatalysis

Mechanistic Complexity in Organo–SOMO Activation

Enantioselective Organo-SOMO Cascade Cycloadditions: A Rapid Approach to Molecular Complexity from Simple Aldehydes and Olefins

Concerning the Mechanism of the FeCl3-Catalyzed α–Oxyamination of Aldehydes: Evidence for a Non-SOMO Activation Pathway

The Organocatalytic Three-Step Total Synthesis of (+)-Frondosin B

Nature of Intermediates in Organo-SOMO Catalysis of α-Arylation of Aldehydes

Enantioselective Polyene Cyclization via Organo-SOMO Catalysis

The Productive Merger of Iodonium Salts and Organocatalysis: A Non-photolytic Approach to the Enantioselective α-Trifluoromethylation of Aldehydes

Nine-Step Enantioselective Total Synthesis of (+)-Minfiensine

Development of a General, Enantioselective Organocatalytic Mukaiyama–Michael Reaction with α,β-Unsaturated Aldehydes

*** Tetrahedron Prize for Creativity in Organic Chemistry, Larry Overman

Enantioselective Aldehyde α-Nitroalkylation via Oxidative Organocatalysis

Enantioselective α-Arylation of Aldehydes via Organo-SOMO Catalysis. An Ortho-Selective Arylation Reaction Based on an Open-Shell Pathway

Enantioselective α-Trifluoromethylation of Aldehydes via Photoredox Organocatalysis

Enantioselective Linchpin Catalysis by SOMO Catalysis: An Approach to the Asymmetric α-Chlorination of Aldehydes and Terminal Epoxide Formation

Cycle-Specific Organocascade Catalysis: Application to Olefin Hydroamination, Hydro-oxidation, and Amino-oxidation, and to Natural Product Synthesis

A Process for the Rapid Removal of Dialkylamino-Substituents From Aromatic Rings. Application to the Expedient Synthesis of (R)-Tolterodine

*** Tetrahedron Young Investigator Award, Justin Du Bois

Enantioselective Organo-Singly Occupied Molecular Orbital Catalysis: The Carbo-oxidation of Styrenes

The Advent and Development of Organocatalysis

Merging Photoredox Catalysis with Organocatalysis: The Direct Asymmetric Alkylation of Aldehydes

Total Synthesis and Structural Revision of Callipeltoside C

Enantioselective Organo-SOMO Catalysis: The α-Vinylation of Aldehydes

Enantioselective Organocatalytic Transfer Hydrogenation Reactions using Hantzsch Esters

*** Special Issue on Hydrogenation & Transfer Hydrogenation

Organocatalytic Vinyl and Friedel–Crafts Alkylations with Trifluoroborate Salts

Strategies to Bypass the Taxol Problem. Enantioselective Cascade Catalysis, a New Approach for the Efficient Construction of Molecular Complexity

Enantioselective Organocatalytic Singly Occupied Molecular Orbital Activation: The Enantioselective α-Enolation of Aldehydes

Enantioselective Organocatalysis Using SOMO Activation

Organocatalytic Transfer Hydrogenation of Cyclic Enones

Enantioselective Organocatalytic Epoxidation Using Hypervalent Iodine Reagents

***Tetrahedron Young Investigator Award, David MacMillan

Enantioselective Organocatalytic Amine Conjugate Addition

Modern Strategies in Organic Catalysis: The Advent and Development of Iminium Activation

Enantioselective Organocatalytic Reductive Amination

Enantioselective Organo-Cascade Catalysis

Enantioselective Organocatalytic Intramolecular Diels-Alder Reactions. The Asymmetric Synthesis of Solanapyrone D

Enantioselective Organocatalytic α-Fluorination of Aldehydes

Total Synthesis of Brasoside and Littoralisone

Enantioselective Organocatalytic Cyclopropanations. The Identification of a New Class of Iminium Catalyst Based upon Directed Electrostatic Activation

Enantioselective Organocatalytic Hydride Reduction

The Importance of Iminium Geometry Control in Enamine Catalysis: Identification of a New Catalyst Architecture for Aldehyde–Aldehyde Couplings

Two Step Synthesis of Carbohydrates by Selective Aldol Reactions

Enantioselective Organocatalytic Aldehyde–Aldehyde Cross-Aldol Couplings. The Broad Utility of α-Thioacetal Aldehydes

*** Tetrahedron Prize for Creativity in Organic Chemistry, Dieter Seebach

Enantioselective Organocatalytic Construction of Pyrroloindolines by a Cascade Addition–Cyclization Strategy: Synthesis of (
–)-Flustramine B

Direct and Enantioselective Organocatalytic α-Chlorination of Aldehydes

Enantioselective Organocatalytic Direct Aldol Reactions of α-Oxyaldehydes: Step One in a Two Step Synthesis of Carbohydrates

The Direct and Enantioselective Organocatalytic α-Oxidation of Aldehydes

The First Suzuki Cross-Couplings of Aryltrimethylammonium Salts

The First Enantioselective Organocatalytic Mukaiyama-Michael Reaction: A Direct Method for the Synthesis of Enantioenriched γ-Butenolide Architecture

Development of a New Lewis Acid-Catalyzed [3,3]-Sigmatropic Rearrangement: The Allenoate-Claisen Rearrangement

The Enantioselective Organocatalytic 1,4-Addition of Electron-Rich Benzenes to α,β-Unsaturated Aldehydes

The First Direct and Enantioselective Cross-Aldol Reaction of Aldehydes

The First General Enantioselective Catalytic Diels-Alder Reaction with Simple α,β-Unsaturated Ketones

Enantioselective Organocatalytic Indole Alkylations. Design of a New and Highly Effective Chiral Amine for Iminium Catalysis

New Strategies in Organic Catalysis: The First Enantioselective Organocatalytic Friedel-Crafts Alkylation

Enantioselective Claisen Rearrangements: Development of a First Generation Asymmetric Acyl-Claisen Reaction

Design of a New Cascade Reaction for the Construction of Complex Acyclic Architecture: The Tandem Acyl-Claisen Rearrangement

New Strategies for Organic Catalysis: The First Enantioselective Organocatalytic 1,3-Dipolar Cycloaddition

New Strategies for Organic Catalysis: The First Highly Enantioselective Organocatalytic Diels-Alder Reaction

Development of a New Lewis Acid-Catalyzed Claisen Rearrangement