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Publications

2021

  • Ligand-to-Copper Charge Transfer: A General Catalytic Approach to Aromatic Decarboxylative Functionalization

    T. Q. Chen, P. S. Pedersen, N. W. Dow, R. Fayad, C. E. Hauke, M. C. Rosko, E. O. Danilov, D. C. Blakemore, A.-M. Dechert-Schmitt, T. Knauber, F. N. Castellano, D. W. C. MacMillan
  • Rapid Optimization of Photoredox Reactions for Continuous-Flow Systems Using Microscale Batch Technology

    M. González-Esguevillas, D. F. Fernández, J. A. Rincón, M. Barberis, O. de Frutos, C. Mateos, S. García-Cerrada, J. Agejas, D. W. C. MacMillan
  • The Application of Pulse Radiolysis to the Study of Ni(I) Intermediates in Ni-Catalyzed Cross-Coupling Reactions

    N. A. Till, S. Oh, D. W. C. MacMillan, M. J. Bird
  • A general N-alkylation platform via copper metallaphotoredox and silyl radical activation of alkyl halides

    N. W. Dow, A. Cabré, D. W. C.MacMillan
  • Decatungstate-Catalyzed C(sp3)−H Sulfinylation: Rapid Access to Diverse Organosulfur Functionality

    P. J. Sarver, N. B. Bissonnette, D. W. C. MacMillan
  • Site-selective tyrosine bioconjugation via photoredox catalysis for native-to-bioorthogonal protein transformation

    B. X. Li, D. K. Kim, S. Bloom, R. Y.-C. Huang, J. X. Qiao, W. R. Ewing , D. G. Oblinsky, G. D. Scholes, D. W. C. MacMillan
  • Reactive intermediates for interactome mapping

    C. P. Seath, A. D. Trowbridge, T. W. Muir, D. W. C. MacMillan
  • Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery

    R. W. Pipal, K. T. Stout, P. Z. Musacchio, S. Ren, T. J. A. Graham, S. Verhoog, L. Gantert, T. G. Lohith, A. Schmitz, H. S. Lee, D. Hesk, E. D. Hostetler, I. W. Davies, D. W. C. MacMillan

2020

  • Site-Selective Functionalization of Methionine Residues via Photoredox Catalysis

    J. Kim, B. X. Li, R. Y.-C. Huang, J. X. Qiao, W. R. Ewing, D. W. C. MacMillan
  • Metallaphotoredox Perfluoroalkylation of Organobromide

    X. Zhao, D. W. C. MacMillan
  • Decarboxylative Oxygenation via Photoredox Catalysis

    T. M. Faraggi, W. Li, D. W. C. MacMillan
  • Mechanistic Analysis of Metallaphotoredox C−N Coupling:Photocatalysis Initiates and Perpetuates Ni(I)/Ni(III) Coupling Activity

    N. A. Till, L. Tian, Z. Dong, G. D. Scholes, D. W. C. MacMillan
  • Static to inducibly dynamic stereocontrol: The convergent use of racemic β-substituted ketones

    J. S. DeHovitz, Y. Y. Loh, J. A. Kautzky, K. Nagao, A. J. Meichan, M. Yamauchi, D. W. C. MacMillan, T. K. Hyster
  • HARC as an open-shell strategy to bypass oxidative addition in Ullmann–Goldberg couplings

    M. N. Lavagnino, T. Liang, D. W. C. MacMillan
  • Cross-Electrophile Coupling of Unactivated Alkyl Chlorides

    H. Sakai*, W. Liu*, C. Le, D. W. C. MacMillan
  • The merger of decatungstate and copper catalysis to enable aliphatic C(sp3)–H trifluoromethylation

    P. J. Sarver*, V. Bacauanu*, D. M. Schultz, D. A. DiRocco, Y.-H. Lam, E. C. Sherer, D. W. C. MacMillan
  • Microenvironment mapping via Dexter energy transfer on immune cells

    J. B. Geri*, J. V. Oakley*, T. Reyes-Robles*, T. Wang*, S. McCarver, C. H. White, F. P. Rodriguez-Rivera, D. L. Parker Jr., E. C. Hett, O. O. Fadeyi, R. C. Oslund, D. W. C. MacMillan
  • Copper-mediated synthesis of drug-like bicyclopentanes

    X. Zhang, R. Smith, C. Le, S. McCarver, B. Shireman, N. Carruthers, D. W. C. MacMillan
  • Transient Absorption Spectroscopy Offers Mechanistic Insights for an Iridium/Nickel-Catalyzed C−O Coupling

    L. Tian, N. A. Till, B. Kudisch, D. W. C. MacMillan, G. D. Scholes

2019

  • Open-Shell Fluorination of Alkyl Bromides: Unexpected Selectivity in a Silyl Radical-Mediated Chain Process

    G. H. Lovett, S. Chen, X.-S. Xue, K. N. Houk, D. W. C. MacMillan
  • A Metallaphotoredox Strategy for the Cross-Electrophile Coupling of Alpha-Chloro Carbonyls with Aryl Halides

    T. Q. Chen, D. W. C. MacMillan
  • Photoredox-catalyzed deoxyfluorination of activated alcohols with Selectfluor

    **Tetrahedron Prize for Creativity in Organic Chemistry, Steve Buchwald

    M. González-Esguevillas, J. Miró, J. L. Jeffrey, D. W. C. MacMillan
  • Copper-Catalyzed Trifluoromethylation of Alkyl Bromides

    D. J. P. Kornfilt, D. W. C. MacMillan

2018

  • Metallaphotoredox-Catalyzed Cross-Electrophile Csp3−Csp3 Coupling of Aliphatic Bromides

    R. T. Smith, X. Zhang, J. A. Rincón, J. Agejas, C. Mateos, M. Barberis, S. García-Cerrada, O. de Frutos, D. W. C. MacMillan
  • Metallaphotoredox Difluoromethylation of Aryl Bromides

    V. Bacauanu, S. Cardinal, M. Yamauchi, M. Kondo, D. F. Fernández, R. Remy, D. W. C. MacMillan
  • Direct arylation of strong aliphatic C–H bonds

    I. B. Perry, T. F. Brewer, P. J. Sarver, D. M. Schultz, D. A. DiRocco, D. W. C. MacMillan
  • Decarboxylative sp3 C–N coupling via dual copper and photoredox catalysis

    Y. Liang, X. Zhang, D. W. C. MacMillan
  • A radical approach to the copper oxidative addition problem: Trifluoromethylation of bromoarenes

    C. Le*, T. Q. Chen*, T. Liang*, P. Zhang, D. W. C. MacMillan
  • Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids

    J. A. Kautzky*, T. Wang*, R. W. Evans, D. W. C. MacMillan
  • Decarboxylative Hydroalkylation of Alkynes

    N. A. Till, R. T. Smith, D. W. C. MacMillan
  • Selective Hydrogen Atom Abstraction through Induced Bond Polarization: Direct α-Arylation of Alcohols through Photoredox, HAT, and Nickel Catalysis

    J. Twilton, M. Christensen, D. A. DiRocco, R. T. Ruck, I. W. Davies, D. W. C MacMillan
  • Sulfonamidation of Aryl and Heteroaryl Halides through Photosensitized Nickel Catalysis

    T. Kim, S. J. McCarver, C. Lee, D. W. C. MacMillan
  • Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols

    E. D. Nacsa, D. W. C. MacMillan

2017

  • Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials

    S. Bloom, C. Liu, D. K. Kölmel, J. X. Qiao, Y. Zhang, M. A. Poss, W. R. Ewing, D. W. C. MacMillan
  • Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

    Y.Y. Loh, K. Nagao, A. J. Hoover, D. Hesk, N. R. Rivera, S. L. Colletti, I. W. Davies, D. W. C. MacMillan
  • Direct Aldehyde C–H Arylation and Alkylation via the Combination of Nickel, Hydrogen Atom Transfer, and Photoredox Catalysis

    X. Zhang, D. W. C. MacMillan
  • Catalyst-Controlled Oligomerization for the Collective Synthesis of Polypyrroloindoline Natural Products

    C. R. Jamison, J. J. Badillo, J. M. Lipshultz, R. J. Comito, D. W. C. MacMillan
  • The Merger of Transition Metal and Photocatalysis

    J. Twilton, C. C. Le, P. Zhang, M. H. Shaw, R. W. Evans, D. W. C. MacMillan
  • Direct, Enantioselective α-Alkylation of Aldehydes using Simple Olefins

    A. G. Capacci, J. T. Malinowski, N. J. McAlpine, J. Kuhne, D. W. C. MacMillan
  • Selective sp3 C–H Alkylation via Polarity-Match-Based Cross-Coupling

    C. Le, Y. Liang, R. W. Evans, X. Li, D. W. C. MacMillan
  • A General Small-Scale Reactor to Enable Standardization and Acceleration of Photocatalytic Reactions

    C. C. Le, M. K. Wismer, Z.-C. Shi, R. Zhang, D. V. Conway, G. Li, P. Vachal, I. W. Davies, D. W. C. MacMillan
  • Photosensitized, Energy Transfer-Mediated Organometallic Catalysis Through Electronically Excited Nickel(II)

    E. R. Welin, C. C. Le, D. M. Arias-Rotondo, J. K. McCusker, D. W. C. MacMillan
  • Decarboxylative Peptide Macrocyclization through PhotoredoCatalysis
    S. J. McCarver, J. X. Qiao, J. Carpenter, R. M. Borzilleri, M. A. Poss, M. D. Eastgate, M. Miller, D. W. C. MacMillan

2016

  • Alcohols as Latent Coupling Fragments for Metallaphotoredox Catalysis: sp3–sp2 Cross-Coupling of Oxalates with Aryl Halides

    X. Zhang, D. W. C. MacMillan
  • Metallaphotoredox-Catalysed sp3–sp3 Cross-Coupling of Carboxylic Acids with Alkyl Halides

    C. P. Johnston, R. T. Smith, S. Allmendinger, D. W. C. MacMillan
  • Photoredox Catalysis in Organic Chemistry

    M. H. Shaw, J. Twilton, D. W. C. MacMillan
  • Aryl Amination Using Ligand-Free Ni(II) Salts and Photoredox Catalysis

    E. B. Corcoran, M. T. Pirnot, S. Lin, S. D. Dreher, D. A. DiRocco, I. W. Davies, S. L. Buchwald, D. W. C. MacMillan
  • Silyl Radical Activation of Alkyl Halides in Metallaphotoredox Catalysis: A Unique Pathway for Cross-Electrophile Coupling

    P. Zhang, C. C. Le, D. W. C. MacMillan
  • Native Functionality in Triple Catalytic Cross-Coupling: sp3 C–H Bonds as Latent Nucleophiles

    M. H. Shaw, V. W. Shurtleff, J. A. Terrett, J. D. Cuthbertson, D. W. C. MacMillan
  • Oxy-Allyl Cation Catalysis: An Enantioselective Electrophilic Activation Mode

    C. Liu, E. Z. Oblak, M. N, Vander Wal, A. K. Dilger, D. K. Almstead, D. W. C. MacMillan
  • Enantioselective Decarboxylative Arylation of α-Amino Acids via the Merger of Photoredox and Nickel Catalysis

    Z. Zuo, H. Cong, W. Li, J. Choi, G. C. Fu, D. W. C. MacMillan

2015

  • Fragment Couplings via CO2 Extrusion−Recombination: Expansion of a Classic Bond-Forming Strategy via Metallaphotoredox

    C. C. Le, D. W. C. MacMillan
  • Oxalates as Activating Groups for Alcohols in Visible Light Photoredox Catalysis: Formation of Quaternary Centers by Redox-Neutral Fragment Coupling

    C. C. Nawrat, C. R. Jamison, Y. Slutskyy, D. W. C. MacMillan, L. E. Overman
  • O–H Hydrogen Bonding Promotes H-Atom Transfer from a C–H bonds for α-Alkylation of Alcohols

    J. L. Jeffrey, J. A. Terrett, D. W. C. MacMillan
  • Alcohols as Alkylating Agents in Heteroarene C–H Functionalization

    J. Jin, D. W. C. MacMillan
  • Switching on Elusive Organometallic Mechanisms with Photoredox Catalysis

    J. A. Terrett, J. D. Cuthbertson, V. W. Shurtleff, D. W. C. MacMillan
  • Enantioselective α-Alkylation of Aldehydes by Photoredox Organocatalysis: Rapid Access to Pharmacophore Fragments from β-Cyanoaldehydes

    E. R. Welin, A. A. Warkentin, J. C. Conrad, D. W. C. MacMillan
  • Selective Radical−Radical Cross-Couplings: Design of a Formal β‑Mannich Reaction

    J. Jeffrey, F. R. Petronijević, D. W. C. MacMillan
  • Merging Photoredox and Nickel Catalysis: The Direct Synthesis of Ketones by the Decarboxylative Arylation of α-Oxo Acids

    L. Chu, J. M. Lipshultz, D. W. C. MacMillan
  • Decarboxylative Fluorination of Aliphatic Carboxylic Acids via Photoredox Catalysis

    S. Ventre, F. R. Petronijević, D. W. C. MacMillan
  • The Direct Arylation of Allylic sp3 C–H Bonds via Organic and Photoredox Catalysis

    J. D. Cuthbertson, D. W. C. MacMillan
  • Merging Photoredox and Nickel Catalysis: Decarboxylative Cross-Coupling of Carboxylic Acids with Vinyl Halides

    A. Noble, S. J. McCarver, D. W. C. MacMillan
  • Direct α-Arylation of Ethers through the Combination of Photoredox–Mediated C–H Functionalization and the Minisci Reaction

    J. Jin, D. W. C. MacMillan

2014

  • Activation of C−H Bonds via the Merger of Photoredox and Organocatalysis: A Coupling of Benzylic Ethers with Schiff Bases

    D. Hager, D. W. C. MacMillan
  • Amine α-Heteroarylation via Photoredox Catalysis: A Homolytic Aromatic Substitution Pathway

    C. K. Prier, D. W. C. MacMillan
  • Photoredox α‑Vinylation of α‑Amino Acids and N‑Aryl Amines

    A. Noble, D. W. C. MacMillan
  • Carboxylic Acids as A Traceless Activation Group for Conjugate Additions: A Three-Step Synthesis of (±)-Pregabalin

    L. Chu, C. Ohta, Z. Zuo, D. W. C. MacMillan
  • Merging Photoredox with Nickel Catalysis: Coupling of α-Carboxyl sp3-Carbons with Aryl Halides

    Z. Zuo, D. T. Ahneman, L. Chu, J. A. Terrett, A. G. Doyle, D. W. C. MacMillan
  • Direct β‑Alkylation of Aldehydes via Photoredox Organocatalysis

    J. A. Terrett, M. D. Clift, D. W. C. MacMillan
  • A General and Enantioselective Approach to Pentoses: A Rapid Synthesis of PSI-6130, the Nucleoside Core of Sofosbuvir

    M. Peifer, R. Berger, V. W. Shurtleff, J. C. Conrad, D. W. C. MacMillan
  • Decarboxylative Arylation of α‑Amino Acids via Photoredox Catalysis: A One-Step Conversion of Biomass to Drug Pharmacophore

    Z. Zuo, D. W. C. MacMillan
  • A General Strategy for Organocatalytic Activation of C−H Bonds via Photoredox Catalysis: Direct Arylation of Benzylic Ethers

    K. Qvortrup, D. A. Rankic, D. W. C. MacMillan

2013

  • Direct β‑Functionalization of Cyclic Ketones with Aryl Ketones via the Merger of Photoredox and Organocatalysis

    F. R. Petronijević, M. Nappi, D. W. C. MacMillan
  • Simple Catalytic Mechanism for the Direct Coupling of α‑Carbonyls with Functionalized Amines: A One-Step Synthesis of Plavix

    R. W. Evans, J. R. Zbieg, S. Zhu, W. Li, D. W. C. MacMillan
  • Enantioselective Total Synthesis of (−)-Minovincine in Nine Chemical Steps: An Approach to Ketone Activation in Cascade Catalysis

    B. N. Laforteza, M. Pickworth, D. W. C. MacMillan
  • Enantioselective α‑Alkenylation of Aldehydes with Boronic Acids via the Synergistic Combination of Copper(II) and Amine Catalysis

    J. M. Stevens, D. W. C. MacMillan
  • Enantioselective Direct α‑Amination of Aldehydes via a Photoredox Mechanism: A Strategy for Asymmetric Amine Fragment Coupling

    G. Cecere, C. M. König, J. L. Alleva, D. W. C. MacMillan
  • Enantioselective Intramolecular Aldehyde α‑Alkylation with Simple Olefins: Direct Access to Homo-Ene Products

    R. J. Comito, F. G. Finelli, D. W. C. MacMillan
  • Development of a generic activation mode: nucleophilic α-substitution of ketones via oxy-allyl cations

    M. N. Vander Wal, A. K. Dilger, D. W. C. MacMillan
  • Nine-Step Enantioselective Total Synthesis of (−)-Vincorine

    B. D. Horning, D. W. C. MacMillan
  • Photoredox Activation for the Direct β-Arylation of Ketones and Aldehydes

    M. T. Pirnot, D. A. Rankic, D. B. C. Martin, D. W. C. MacMillan
  • Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis

    C. K. Prier, D. A. Rankic, D. W. C. MacMillan

2012

  • Enantioselective Organo-SOMO Cycloadditions: A Catalytic Approach to Complex Pyrrolidines from Olefins and Aldehydes

    N. T. Jui, J. A. O. Garber, F. G. Finelli, D. W. C. MacMillan
  • Enantioselective Copper-Catalyzed Construction of Aryl Pyrroloindolines via an Arylation−Cyclization Cascade

    S. Zhu, D. W. C. MacMillan
  • Enantioselective α-Vinylation of Aldehydes via the Synergistic Combination of Copper and Amine Catalysis

    E. Skucas, D. W. C. MacMillan
  • Synergistic Catalysis: A Powerful Synthetic Strategy for New Reaction Development

    A. E. Allen, D. W. C. MacMillan
  • A General Approach to the Enantioselective α-Oxidation of Aldehydes via Synergistic Catalysis

    S. P. Simonovich, J. F. Van Humbeck, D. W. C. MacMillan

2011

  • Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis

    D. A. Nagib, D. W. C. MacMillan
  • Discovery of an α-Amino C–H Arylation Reaction Using the Strategy of Accelerated Serendipity

    A. McNally, C. K. Prier, D. W. C. MacMillan
  • Enantioselective α-Arylation of Carbonyls via Cu(I)-Bisoxazoline Catalysis

    J. S. Harvey, S. P. Simonovich, C. R. Jamison, D. W. C. MacMillan
  • Collective Synthesis of Natural Products By Means of Organocascade Catalysis

    S. B. Jones, B. Simmons, A. Mastracchio, D. W. C. MacMillan
  • Photoredox Catalysis: A Mild, Operationally Simple Approach to the Synthesis of α-Trifluoromethyl Carbonyl Compounds

    P. V. Pham, D. A. Nagib, D. W. C. MacMillan
  • The Intramolecular Asymmetric Allylation of Aldehydes via Organo-SOMO Catalysis: A Novel Approach to Ring Construction

    P. V. Pham, K. Ashton, D. W. C. MacMillan
  • Enantioselective α-Arylation of Aldehydes via the Productive Merger of Iodonium Salts and Organocatalysis

    A. E. Allen, D. W. C. MacMillan
  • Enantioselective Organocatalytic α-Fluorination of Cyclic Ketones

    P. Kwiatkowski, T. D. Beeson, J. C. Conrad, D. W. C. MacMillan
  • Total Synthesis of Diazonamide A

    R. R. Knowles, J. Carpenter, S. B. Blakey, A. Kayano, I. K. Mangion, C. J. Sinz, D. W. C. MacMillan
  • The Preparation of (2R,5S)-2-t-butyl-3,5- Dimethylimidazolidin-4-one

    T. H. Graham, B. D. Horning, D. W. C. MacMillan

2010

  • Direct and Enantioselective α-Allylation of Ketones via Singly Occupied Molecular Orbital (SOMO) Catalysis

    *** Special Issue on Organocatalysis

    A. Mastracchio, A. A. Warkentin, A. M. Walji, D. W. C. MacMillan
  • Enantioselective α-Benzylation of Aldehydes via Photoredox Organocatalysis

    H.-W. Shih, M. N. Vander Wal, R. L. Grange, D. W. C. MacMillan
  • Mechanistic Complexity in Organo–SOMO Activation

    J. J. Devery III, J. C. Conrad, D. W. C. MacMillan, R. A. Flowers II
  • Enantioselective Organo-SOMO Cascade Cycloadditions: A Rapid Approach to Molecular Complexity from Simple Aldehydes and Olefins

    N. T. Jui, E. C. Y. Lee, D. W. C. MacMillan
  • Concerning the Mechanism of the FeCl3-Catalyzed αOxyamination of Aldehydes: Evidence for a Non-SOMO Activation Pathway

    J. F. Van Humbeck, S. P. Simonovich, R. R. Knowles, D. W. C. MacMillan
  • The Organocatalytic Three-Step Total Synthesis of (+)-Frondosin B

    M. Reiter, S. Torssell, S. Lee, D. W. C. MacMillan
  • Nature of Intermediates in Organo-SOMO Catalysis of α-Arylation of Aldehydes

    J. M. Um, O. Gutierrez, F. Schoenebeck, K. N. Houk, D. W. C. MacMillan
  • Enantioselective Polyene Cyclization via Organo-SOMO Catalysis

    S. Rendler, D. W. C. MacMillan
  • The Productive Merger of Iodonium Salts and Organocatalysis: A Non-photolytic Approach to the Enantioselective α-Trifluoromethylation of Aldehydes

    A. E. Allen, D. W. C. MacMillan

2009

  • Nine-Step Enantioselective Total Synthesis of (+)-Minfiensine

    S. B. Jones, B. Simmons, D. W. C. MacMillan
  • Development of a General, Enantioselective Organocatalytic Mukaiyama–Michael Reaction with α,β-Unsaturated Aldehydes

    *** Tetrahedron Prize for Creativity in Organic Chemistry, Larry Overman

    C. J. Borths, D. E. Carrera, D. W. C. MacMillan
  • Enantioselective Aldehyde α-Nitroalkylation via Oxidative Organocatalysis

    J. E. Wilson, A. D. Casarez, D. W. C. MacMillan
  • Enantioselective α-Arylation of Aldehydes via Organo-SOMO Catalysis. An Ortho-Selective Arylation Reaction Based on an Open-Shell Pathway

    J. C. Conrad, J. Kong, B. N. Laforteza, D. W. C. MacMillan
  • Enantioselective α-Trifluoromethylation of Aldehydes via Photoredox Organocatalysis

    D. A. Nagib, M. E. Scott, D. W. C. MacMillan
  • Enantioselective Linchpin Catalysis by SOMO Catalysis: An Approach to the Asymmetric α-Chlorination of Aldehydes and Terminal Epoxide Formation

    M. Amatore, T. D. Beeson, S. P. Brown, D. W. C. MacMillan
  • Cycle-Specific Organocascade Catalysis: Application to Olefin Hydroamination, Hydro-oxidation, and Amino-oxidation, and to Natural Product Synthesis

    B. Simmons, A. Walji, D. W. C. MacMillan
  • A Process for the Rapid Removal of Dialkylamino-Substituents From Aromatic Rings. Application to the Expedient Synthesis of (R)-Tolterodine

    *** Tetrahedron Young Investigator Award, Justin Du Bois

    N. Paras, B. Simmons, D. W. C. MacMillan

2008

  • Enantioselective Organo-Singly Occupied Molecular Orbital Catalysis: The Carbo-oxidation of Styrenes

    T. H. Graham, C. M. Jones, N. T. Jui, D. W. C. MacMillan
  • The Advent and Development of Organocatalysis

    D. W. C. MacMillan
  • Merging Photoredox Catalysis with Organocatalysis: The Direct Asymmetric Alkylation of Aldehydes

    D. Nicewicz, D. W. C. MacMillan
  • Total Synthesis and Structural Revision of Callipeltoside C

    J. Carpenter, A. B. Northrup, d. M. Chung, J. J. M. Wiener, S.-G. Kim, D. W. C. MacMillan
  • Enantioselective Organo-SOMO Catalysis: The α-Vinylation of Aldehydes

    H. Kim, D. W. C. MacMillan

2007

  • Enantioselective Organocatalytic Transfer Hydrogenation Reactions using Hantzsch Esters

    *** Special Issue on Hydrogenation & Transfer Hydrogenation

    S. G. Ouellet, A. Walji, D. W. C. MacMillan
  • Organocatalytic Vinyl and Friedel–Crafts Alkylations with Trifluoroborate Salts

    S. Lee, D. W. C. MacMillan
  • Strategies to Bypass the Taxol Problem. Enantioselective Cascade Catalysis, a New Approach for the Efficient Construction of Molecular Complexity

    A. Walji, D. W. C. MacMillan
  • Enantioselective Organocatalytic Singly Occupied Molecular Orbital Activation: The Enantioselective α-Enolation of Aldehydes

    H.-Y. Jang, J.-B. Hong, D. W. C. MacMillan
  • Enantioselective Organocatalysis Using SOMO Activation

    T. D. Beeson, A. Mastracchio, J.-B. Hong, K. Ashton, D. W. C. MacMillan

2006

  • Organocatalytic Transfer Hydrogenation of Cyclic Enones

    J. B. Tuttle, S. G. Ouellet, D. W. C. MacMillan
  • Enantioselective Organocatalytic Epoxidation Using Hypervalent Iodine Reagents

    ***Tetrahedron Young Investigator Award, David MacMillan

    S. Lee, D. W. C. MacMillan
  • Enantioselective Organocatalytic Amine Conjugate Addition

    Y. K. Chen, M. Yoshida, D. W. C. MacMillan
  • Modern Strategies in Organic Catalysis: The Advent and Development of Iminium Activation

    G. Lelais, D. W. C. MacMillan
  • Enantioselective Organocatalytic Reductive Amination

    R. I. Storer, D. E. Carrera, Y. Ni, D. W. C. MacMillan

2005

  • Enantioselective Organo-Cascade Catalysis

    Y. Huang, A. M. Walji, C. H. Larsen, D. W. C. MacMillan
  • Enantioselective Organocatalytic Intramolecular Diels-Alder Reactions. The Asymmetric Synthesis of Solanapyrone D

    R. M. Wilson, W. S. Jen, D. W. C. MacMillan
  • Enantioselective Organocatalytic α-Fluorination of Aldehydes

    T. D. Beeson, D. W. C. MacMillan
  • Total Synthesis of Brasoside and Littoralisone

    I. K. Mangion, D. W. C. MacMillan
  • Enantioselective Organocatalytic Cyclopropanations. The Identification of a New Class of Iminium Catalyst Based upon Directed Electrostatic Activation

    R. K. Kunz, D. W. C. MacMillan
  • Enantioselective Organocatalytic Hydride Reduction

    S. G. Ouellet, J. B. Tuttle, D. W. C. MacMillan

2004

  • The Importance of Iminium Geometry Control in Enamine Catalysis: Identification of a New Catalyst Architecture for Aldehyde–Aldehyde Couplings

    I. K. Mangion, A. B. Northrup, D. W. C. MacMillan
  • Two Step Synthesis of Carbohydrates by Selective Aldol Reactions

    A. B. Northrup, D. W. C. MacMillan
  • Enantioselective Organocatalytic Aldehyde–Aldehyde Cross-Aldol Couplings. The Broad Utility of α-Thioacetal Aldehydes

    *** Tetrahedron Prize for Creativity in Organic Chemistry, Dieter Seebach

    R. I. Storer, D. W. C. MacMillan
  • Enantioselective Organocatalytic Construction of Pyrroloindolines by a Cascade Addition–Cyclization Strategy: Synthesis of (–)-Flustramine B

    J. F. Austin, S. G. Kim, C. J. Sinz, W. J. Xiao, D. W. C. MacMillan
  • Direct and Enantioselective Organocatalytic α-Chlorination of Aldehydes

    M. P. Brochu, S. P. Brown, D. W. C. MacMillan
  • Enantioselective Organocatalytic Direct Aldol Reactions of α-Oxyaldehydes: Step One in a Two Step Synthesis of Carbohydrates

    A. B. Northrup, I. K. Mangion, F. Hettche, D. W. C. MacMillan

2003

  • The Direct and Enantioselective Organocatalytic α-Oxidation of Aldehydes

    S. P. Brown, M. P. Brochu, C. J. Sinz, D. W. C. MacMillan
  • The First Suzuki Cross-Couplings of Aryltrimethylammonium Salts

    S. B. Blakey, D. W. C. MacMillan
  • The First Enantioselective Organocatalytic Mukaiyama-Michael Reaction: A Direct Method for the Synthesis of Enantioenriched γ-Butenolide Architecture

    S. P. Brown, N. C. Goodwin, D. W. C. MacMillan

2002

  • Development of a New Lewis Acid-Catalyzed [3,3]-Sigmatropic Rearrangement: The Allenoate-Claisen Rearrangement

    T. H. Lambert, D. W. C. MacMillan
  • The Enantioselective Organocatalytic 1,4-Addition of Electron-Rich Benzenes to α,β-Unsaturated Aldehydes

    N. A. Paras, D. W. C. MacMillan
  • The First Direct and Enantioselective Cross-Aldol Reaction of Aldehydes

    A. B. Northrup, D. W. C. MacMillan
  • The First General Enantioselective Catalytic Diels-Alder Reaction with Simple α,β-Unsaturated Ketones

    A. B. Northrup, D. W. C. MacMillan
  • Enantioselective Organocatalytic Indole Alkylations. Design of a New and Highly Effective Chiral Amine for Iminium Catalysis

    J. F. Austin, D. W. C. MacMillan

2001

  • New Strategies in Organic Catalysis: The First Enantioselective Organocatalytic Friedel-Crafts Alkylation

    N. A. Paras, D. W. C. MacMillan
  • Enantioselective Claisen Rearrangements: Development of a First Generation Asymmetric Acyl-Claisen Reaction

    T. P. Yoon, D. W. C. MacMillan
  • Design of a New Cascade Reaction for the Construction of Complex Acyclic Architecture: The Tandem Acyl-Claisen Rearrangement

    V. M. Dong, D. W. C. MacMillan

2000

  • New Strategies for Organic Catalysis: The First Enantioselective Organocatalytic 1,3-Dipolar Cycloaddition

    W. S. Jen, J. J. M. Wiener, D. W. C. MacMillan
  • New Strategies for Organic Catalysis: The First Highly Enantioselective Organocatalytic Diels-Alder Reaction

    K. A. Ahrendt, C. J. Borths, D. W. C. MacMillan

1999

  • Development of a New Lewis Acid-Catalyzed Claisen Rearrangement

    T. P. Yoon, V. M. Dong, D. W. C. MacMillan

Book Chapters

  • Lelais, G.; MacMillan, D. W. C. History and Perspective of Chiral Organic Catalysts. In New Frontiers in Asymmetric Catalysis; Mikami, K., Lautens, M., Eds.; Wiley: Hoboken, New Jersey, 2007; pp 313–358.
  • Lelais, G.; MacMillan, D. W. C. Iminium Catalysis. In Enantioselective Organocatalysis: Reactions and Experimental Procedures; Dalko, P. I., Ed.; Wiley-VCH: Weinheim, 2007; pp 95–120.
  • Watson, A. J. B.; MacMillan, D. W. C. Enantioselective Organocatalysis Involving Iminium, Enamine, SOMO, and Photoredox Activation. In Catalytic Asymmetric Synthesis, 3rd ed.; Ojima, I., Ed.; Wiley: Hoboken, New Jersey, 2010, Chapter 2A, pp 39–57.
  • MacMillan, D. W. C.; Watson, A. J. B. Photoredox Organocatalysis Mediated Enantioselective α-Functionalization. In Science of Synthesis: Stereoselective Synthesis 3. Evans, P.A., Ed.; Thieme: New York, New York, 2011, Chapter 16, pp 675-746.
  • Prier, C. K.; MacMillan, D. W. C. Dual Photoredox Catalysis: The Merger of Photoredox Catalysis with Other Catalytic Activation Modes. In Visible Light Photocatalysis in Organic Chemistry; Stephenson, C. R. J., Yoon, T. P., MacMillan, D. W. C., Eds.; Wiley: Hoboken, New Jersey, 2018, Chapter 10, pp 299-333.